Model Muse version 5 has been released, now with PEST support.
/A major version of Model Muse was released last May 18, 2022 after more than a year from the previous release. This version has some change as the capacity to choose the creation of model archives, options to select objects by name, supports adaptive time stepping for MODFLOW 6, have additional support for MODFLOW packages but most importantly it has capabilities to run PEST for all its functionalities: prediction, regularization and Pareto.
Model Muse is capable of running Pest simulations on Modflow 2005, Sutra and Modflow 6 created with Model Muse and other types of Modflow 6 as discretized by vertices and unstructured grid models on Modflow 6.
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FloPy is the Python library that builds and executes MODFLOW models; this library has been enhanced to provide full support of MODFLOW 6 with most of its recent development is related to functionality for MODFLOW 6, tools to use vector and raster spatial data and common plotting and export functionality.